FAP: IL4/IL13 induction

Pathway ID: SIGNOR-FapIL4View in NDEx

Description: Eosinophils are the main source of IL4 and IL13. These cytokines are able to activate fibro/adipogenic progenitors making them secrete a number of cytokines and growth factors important for satellite cell differentiation. IL4R acts through STAT6 transcription factor to transcribe a number of genes involved in muscle regeneration. The IL4R pathway is also able to repress the adipogenic fate of FAPs through the inhibition of PPAR gamma, a master regulator of adipogenesis.

Curated by: Alessandro Palma

8 Seed Entities

Organism:
Name Primary ID
IL4 P05112
IL4R P24394
PPARG P37231
Adipogenesis SIGNOR-PH26
JAK1 P23458
IL13 P35225
JAK2 O60674
STAT6 P42226