FAP: PDGFR alpha

Pathway ID: SIGNOR-FapPDGFRA

Description: Platelet-derived growth factor receptor alpha (PDGFRa) signaling pathway is activated by PGDF ligands, which bind this receptor with high affinity. This leads to proliferation through two distinct mechanisms: PI3K-Akt and MEK2-MAPK signaling pathways. Moreover, PDGF signaling has been reported to be involved in fibrosis development.

Curated by: Alessandro Palma

8 Seed Entities

Organism:
Name Primary ID
PDGFRA P16234
Proliferation SIGNOR-PH4
PDGFB P01127
imatinib CHEBI:45783
PDGFA P04085
Fibrosis SIGNOR-PH90
ERK1/2 SIGNOR-PF1
AKT1 P31749