| + |
3-Isobutyl-1-methylxanthine | up-regulates 
|
PPARG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209998 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-Isobutyl-1-methylxanthine | up-regulates
, transcriptional regulation
|
CEBPB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8754811 |
The differentiation of 3t3 preadipocytes into adipocytes is accompanied by a transient induction of c/ebpbeta and c/ebpdelta expression in response to treatment of the cells with methylisobutylxanthine (mix) and dexamethasone (dex), respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
3-Isobutyl-1-methylxanthine | down-regulates activity 
chemical inhibition
|
PDE1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
Until now, very few inhibitors of PDE1 were available for evaluating the contribution of PDE1 in tissue and cell function. Vinpocetine (Ahn et al., 1989) and 8-methoxymethyl-IBMX (Ahn et al., 1997) are common PDE1 inhibitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-Isobutyl-1-methylxanthine | down-regulates activity
chemical inhibition
|
PDE1B |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253400 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
Until now, very few inhibitors of PDE1 were available for evaluating the contribution of PDE1 in tissue and cell function. Vinpocetine (Ahn et al., 1989) and 8-methoxymethyl-IBMX (Ahn et al., 1997) are common PDE1 inhibitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-Isobutyl-1-methylxanthine | down-regulates activity
chemical inhibition
|
PDE1C |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253017 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22014080 |
Until now, very few inhibitors of PDE1 were available for evaluating the contribution of PDE1 in tissue and cell function. Vinpocetine (Ahn et al., 1989) and 8-methoxymethyl-IBMX (Ahn et al., 1997) are common PDE1 inhibitors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
3-Isobutyl-1-methylxanthine | up-regulates
|
CEBPA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209992 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11279134 |
The differentiation of 3t3-l1 preadipocytes is regulated in part by a cascade of transcriptional events involving activation of the ccaat/enhancer-binding proteins (c/ebps) and peroxisome proliferator-activated receptor gamma (ppargamma) by dexamethasone (dex), 3-isobutyl-1-methylxanthine (mix), and insulin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
3-Isobutyl-1-methylxanthine
