+ |
PTGS2 | up-regulates
chemical modification
|
dinoprost |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-113291 |
|
|
Homo sapiens |
|
pmid |
sentence |
11751058 |
Cox catalyzes two enzymatic activities;namely, the conversion of aa to the hydroperoxy endoperoxide pgg2, followed by its subsequent reduction to the labile product pgh2. Pgh2_ is the common substrate for a number of different cell-specific synthases, which convert pgh2_ to the individual pgs or tx, including pge2, pgi2_ (prostacyclin), pgd2, pgf2alfa, and txa2. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255359 |
|
|
Homo sapiens |
|
pmid |
sentence |
20219869 |
NSAIDs are strong inhibitors of cycloxygenases (COX), and thereby impair the metabolism of arachidonic acid that is necessary for the synthesis of prostaglandins |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
dinoprost | up-regulates
|
Proliferation |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255360 |
|
|
Homo sapiens |
|
pmid |
sentence |
20219869 |
Prostaglandins are able to affect muscle cell proliferation (142), differentiation (96) and fusion (141), and can also modulate muscle fiber growth and the synthesis and degradation of proteins in muscle |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255362 |
|
|
Homo sapiens |
|
pmid |
sentence |
3308494 |
The results suggest a role for prostanoids in the regulation of both human myoblast proliferation and differentiation |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Skeletal Muscle |
+ |
dinoprost | up-regulates
|
Myoblast_fusion |
0.7 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256213 |
|
|
Homo sapiens |
|
pmid |
sentence |
20219869 |
Prostaglandins are able to affect muscle cell proliferation (142), differentiation (96) and fusion (141), and can also modulate muscle fiber growth and the synthesis and degradation of proteins in muscle |
|
Publications: |
1 |
Organism: |
Homo Sapiens |