3.0
Summary
| Name |  CBX4View Modifications |
| Full Name | E3 SUMO-protein ligase CBX4 |
| Synonyms | Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2 |
| Primary ID | O00257 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CBX4 | down-regulates quantity by destabilization 
sumoylation
|
ZEB2 | 0.337 |
| Publications: | 2 | Organism: | Chlorocebus Aethiops | |
| + | CBX4 | down-regulates activity
sumoylation
|
ZEB2 | 0.337 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5B | up-regulates activity 
binding
|
CBX4 | 0.41 |
| Publications: | 1 | Organism: | Homo Sapiens | |