| + |
BCL9 | up-regulates 
binding
|
CTNNB1 |
0.936 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116552 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11955446 |
Bcl9 exert its function by physically linking pygo to beta-catenin. The recruitment of pygo permits beta-catenin to transcriptionally activate wnt target genes. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15208637 |
The transcriptional activity of beta-catenin depends on bcl-9. Bcl-9 functions in targeting beta-catenin to the nucleus and thus increases the transcriptional activity of beta-catenin |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
BCL9 | up-regulates
binding
|
PYGO1 |
0.902 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-116577 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 11955446 |
Here we report the identification of two segment polarity genes in drosophila, legless (lgs), and pygopus (pygo), and we show that their products are required for wnt signal transduction at the level of nuclear beta-catenin. Lgs encodes the homolog of human bcl9, and we provide genetic and molecular evidence that these proteins exert their function by physically linking pygo to beta-catenin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
BCL9
- 
- 