| + |
FST | down-regulates activity 
binding
|
MSTN |
0.757 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235150 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11459935 |
Binding of myostatin to Act RIIB could be inhibited by the activin-binding protein follistatin and, at higher concentrations, by the myostatin propeptide. T |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251717 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24627466 |
Follistatin (FST) is a member of the tissue growth factor beta family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. FST315-deltaHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
FSTL3 | down-regulates
binding
|
MSTN |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199063 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
Fstl3 inhibits myostatin via its n-terminal domain. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
CEBPD | up-regulates quantity by expression 
transcriptional regulation
|
MSTN |
0.293 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255332 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24011072 |
To identify whether p-Stat3 acts through C/EBPδ to stimulate myostatin, we knocked down C/EBPδ using siRNA. In this case, the IL-6-induced increase in myostatin expression was blocked when C/EBPδwas suppressed even though p-Stat3 was increased |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPARGC1A | down-regulates quantity by repression
transcriptional regulation
|
MSTN |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256151 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23217713 |
PGC-1 alpha specifically induces IGF1 and represses myostatin, and expression of PGC-1a 4 in vitro and in vivo induces robust skeletal muscle hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TDGF1 | down-regulates 
|
MSTN |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192436 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23129614 |
We provide evidence that cripto modulates myogenic cell determination and promotes proliferation by antagonizing the tgf-beta ligand myostatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MSTN | up-regulates activity 
binding
|
ACVR2B |
0.67 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235153 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11459935 |
The purified C-terminal myostatin dimer was capable of binding the activin type II receptors, Act RIIB and, to a lesser extent, Act RIIA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MSTN | down-regulates activity
|
AKT |
0.513 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255339 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19357233 |
In the current study, it was demonstrated that myostatin inhibits activation of Akt, in both myoblasts and myotubes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MSTN
- 
- 