Summary

Name XPO1
Full Name Exportin-1
Synonyms Exp1, Chromosome region maintenance 1 protein homolog | CRM1, CRM1
Primary ID O14980
Links - -
Type protein
Relations 5
Pathways FLT3-ITD signaling
Inhibitors Verdinexor; Selinexor
Function Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations

Regulator Mechanism target score ℹ
+ XPO1down-regulates img/direct_inhibition.png relocalization SMAD4 0.308
Publications: 1 Organism: Homo Sapiens
+ XPO1down-regulates activity img/direct_inhibition.png relocalization TP53 0.572
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling
+ Verdinexordown-regulates img/direct_inhibition.png chemical inhibition XPO1 0.8
Publications: 1 Organism: Homo Sapiens
+ RANup-regulates activity img/direct-activation.png binding XPO1 0.925
Publications: 1
+ Selinexordown-regulates activity img/direct_inhibition.png chemical inhibition XPO1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3-ITD signaling