Summary

Name SMAD6
Full Name Mothers against decapentaplegic homolog 6
Synonyms MAD homolog 6, Mothers against DPP homolog 6, SMAD family member 6, SMAD 6, Smad6, hSMAD6 | MADH6
Primary ID O43541
Links - -
Type protein
Relations 19
Pathways TGF-beta Signaling
Function Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png ubiquitination SMAD6 0.481
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD6 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates activity img/direct_inhibition.png binding SMAD4 0.552
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates img/direct_inhibition.png binding SMAD1/4 0.557
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding TBX6 0.333
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding SMURF1 0.822
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding TGFBR1 0.729
Publications: 2 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ up-regulates img/direct-activation.png binding PELI1 0.338
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation SMAD6 0.578
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding TAB1 0.544
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization SMAD6 0.822
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding SMAD3 0.475
Publications: 1 Organism: Homo Sapiens
Pathways:TGF-beta Signaling
+ down-regulates img/direct_inhibition.png binding SMAD1 0.555
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding MAP3K7 0.546
Publications: 1 Organism: Rattus Norvegicus
Pathways:TGF-beta Signaling
+ down-regulates img/indirect_inhibition.png BMPR1A 0.725
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png binding NR2C2 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding HOXC8 0.55
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation SMAD6 0.555
Publications: 1 Organism: Mus Musculus