Summary

Name SH3BP5
Full Name SH3 domain-binding protein 5
Synonyms SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK | SAB, SAB
Primary ID O60239
Links - -
Type protein
Relations 3
Function Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation SH3BP5 0.456
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation SH3BP5 0.378
Publications: 1 Organism: In Vitro