Summary

Name MAFK
Full Name Transcription factor MafK
Synonyms Erythroid transcription factor NF-E2 p18 subunit
Primary ID O60675
Links - -
Type protein
Relations 3
Function Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding MAFK 0.489
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png binding MAFK 0.383
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding MAFK 0.277
Publications: 1 Organism: In Vitro