Summary

Name DEPDC5
Full Name GATOR complex protein DEPDC5
Synonyms DEPD5_HUMAN | KIAA0645
Primary ID O75140
Links - -
Type protein
Relations 1
Function As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.

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Relations

Regulator Mechanism target score ℹ
+ DEPDC5form complex img/form-complex.png binding GATOR1 0.948
Publications: 1 Organism: Homo Sapiens