| + |
PTP4A3 | down-regulates activity 
dephosphorylation
|
KRT8 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248341 |
Ser432 |
SAYGGLTsPGLSYSL |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 19115206 |
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248340 |
Ser74 |
TVNQSLLsPLVLEVD |
Homo sapiens |
Colonic Cancer Cell |
| pmid |
sentence |
| 19115206 |
the cytoskeletal intermediate filament keratin 8 (KRT8) was identified as a physiological PRL-3-interacting protein. Indeed, treatment with the PRL-3 inhibitor effectively suppressed the phosphorylation of KRT8 at S73 and S431|The site-specific phosphorylation of keratins induces the disassembly of these filaments, and the balance between their phosphorylation and dephosphorylation controls the continuous exchange of intermediate filament subunits between a soluble pool and polymerized filaments |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PTP4A3 | down-regulates activity
dephosphorylation
|
EZR |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248342 |
Thr567 |
QGRDKYKtLRQIRQG |
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 18078820 |
Here we report the identification of Ezrin as a specific and direct cellular substrate of PRL-3. In HCT116 colon cancer cell line, Ezrin was identified among the cellular proteins whose phosphorylation level decreased upon ectopic over-expression of wtPRL-3 but not of catalytically inactive PRL-3 mutants. Although PRL-3 over-expression in HCT116 cells appeared to affect Ezrin phosphorylation status at both tyrosine residues and Thr567, suppression of the endogenous protein by RNA interference pointed to Ezrin-Thr567 as the residue primarily affected by PRL-3 action. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PTP4A3
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