3.0
Summary
| Name |  PPM1BView Modifications |
| Full Name | Protein phosphatase 1B |
| Synonyms | Protein phosphatase 2C isoform beta, PP2C-beta | PP2CB |
| Primary ID | O75688 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPM1B | down-regulates 
dephosphorylation
|
IKBKB | 0.413 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PPM1B | down-regulates activity
dephosphorylation
|
IKBKB | 0.413 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | PPM1B |
dephosphorylation
|
CDK9 | 0.386 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPM1B | down-regulates activity
dephosphorylation
|
PAX2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | HEK-293 Cell | |||
| Pathways: | Focal segmental glomerulosclerosis | |||