3.0
Summary
| Name |  TRIOView Modifications |
| Full Name | Triple functional domain protein |
| Synonyms | PTPRF-interacting protein |
| Primary ID | O75962 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:22155786, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202, PubMed:22155786). Plays a key role in the regulation of neurite outgrowth and lamellipodia formation (PubMed:32109419). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FYN | up-regulates activity 
phosphorylation
|
TRIO | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PTK2 | up-regulates activity
phosphorylation
|
TRIO | 0.481 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | TRIO | up-regulates quantity
binding
|
DCC | 0.582 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | TRIO | up-regulates activity
guanine nucleotide exchange factor
|
RAC1 | 0.673 |
| Publications: | 1 | Organism: | Homo Sapiens | |