| + |
WDR48 | up-regulates activity 
binding
|
USP1 |
0.945 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263274 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18082604 |
In vitro reconstitution of USP1 deubiquitinating enzyme activity, using either ubiquitin-7-amido-4-methylcoumarin (Ub-AMC) or purified monoubiquitinated FANCD2 protein as substrates, demonstrates that UAF1 functions as an activator of USP1. UAF1 binding increases the catalytic turnover (kcat) but does not increase the affinity of the USP1 enzyme for the substrate (KM). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP1 | down-regulates activity 
deubiquitination
|
FANCD2 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263273 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18082604 |
The deubiquitinating enzyme USP1 controls the cellular levels of the DNA damage response protein Ub-FANCD2|The level of monoubiquitinated FANCD2 protein increases in response to various types of DNA damage in mammalian cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP1 | down-regulates activity
deubiquitination
|
FANCI |
0.655 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263272 |
|
|
|
|
| pmid |
sentence |
| 18985065 |
Phosphorylation of FANCI may also turn the ubiquitinated ID complex into a poor substrate for deubiquitination by the USP1–UAF1 complex, resulting in increased levels of monoubiquitinated FANCD2. |
|
| Publications: |
1 |
3.0
USP1
- 
- 