Summary

Name PCNT
Full Name Pericentrin
Synonyms Kendrin, Pericentrin-B | KIAA0402, PCNT2
Primary ID O95613
Links - -
Type protein
Relations 3
Function Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png relocalization PCNT 0.347
Publications: 1
+ up-regulates img/direct-activation.png relocalization PCNT 0.674
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CDK5RAP2 0.813
Publications: 1 Organism: Homo Sapiens