Summary

Name TSPAN12
Full Name Tetraspanin-12
Synonyms Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12 | NET2, TM4SF12
Primary ID O95859
Links - -
Type protein
Relations 1
Function Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Viewer

Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png NDP 0.586
Publications: 1 Organism: Homo Sapiens