Summary

Name IL1B
Full Name Interleukin-1 beta
Synonyms IL-1 beta, Catabolin | IL1F2
Primary ID P01584
Links - -
Type protein
Relations 38
Pathways COVID-19 Causal Network, IL1 Signaling , Inflammosome Activation, Macrophage: IL1 beta, Macrophage: Polarization and myogenesis, Multiple sclerosis, SARS-CoV CYTOKINE STORM, Satellite: IL1 , SARS-CoV INFLAMMATORY RESPONSE, Thyroid Hormone Metabolism
Function Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage IL1B 0.797
Publications: 2 Organism: In Vitro
Pathways:COVID-19 Causal Network, Inflammosome Activation, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IL1B 0.269
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding IL1RAP 0.86
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.535
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png IL1B 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation IL1B 0.569
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, IL1 Signaling , Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
+ down-regulates activity img/indirect_inhibition.png LPL 0.297
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Immune_response 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1B 0.391
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png transcriptional regulation IL1B 0.299
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1B 0.569
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:COVID-19 Causal Network, IL1 Signaling , Inflammosome Activation, Multiple sclerosis, SARS-CoV CYTOKINE STORM, SARS-CoV INFLAMMATORY RESPONSE
+ up-regulates img/direct-activation.png binding IL1R1 0.903
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
Pathways:IL1 Signaling , SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MC1R 0.265
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO1 0.2
Publications: 1 Organism: Rattus Norvegicus
Pathways:Thyroid Hormone Metabolism
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL1B 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation SCNN1A 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL1B 0.313
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation DIO 0.2
Publications: 2 Organism: Rattus Norvegicus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL1B 0.347
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png STAT3 0.572
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA2 0.28
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png transcriptional regulation IL1B 0.536
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation KRT1 0.252
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SERPINA3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png IL1B 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Multiple sclerosis
+ up-regulates activity img/direct-activation.png binding IL1R1 0.903
Publications: 1 Organism: Homo Sapiens
Pathways:IL1 Signaling , SARS-CoV CYTOKINE STORM
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GDF5 0.269
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ENPP1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding IL1R2 0.873
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ITGA3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CTSK 0.343
Publications: 1
+ down-regulates quantity img/indirect_inhibition.png IL1B 0.7
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GCH1 0.354
Publications: 1 Organism: Homo Sapiens
Tissue: Blood Vessel Endothelium