Summary

Name CD8A
Full Name T-cell surface glycoprotein CD8 alpha chain
Synonyms T-lymphocyte differentiation antigen T8/Leu-2 | MAL
Primary ID P01732
Links - -
Type protein
Relations 3
Pathways Mitochondrial dynamics in T cell exhaustion, T cell activation
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding CD8A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD8A 0.315
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD8A 0.261
Publications: 1 Organism: Homo Sapiens