| + |
APOB | up-regulates 
|
LDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252116 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
Apolipoprotein B is a structural protein that is an integral component of chylomicrons, as well as very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) particles. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOB | up-regulates
|
VLDL_assembly |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252115 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
Apolipoprotein B is a structural protein that is an integral component of chylomicrons, as well as very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) particles. In man, VLDL contains only ApoB100, the full length protein |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RAD21 | down-regulates quantity 
transcriptional regulation
|
APOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259974 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25575569 |
The promoter region of APOB bound RAD21 but not RAD21 p.622 Ala>Thr; expression of wild-type RAD21 in HEK293 cells repressed expression of APOB, compared with control vector. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | up-regulates quantity by stabilization
|
APOB |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251755 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8611031 |
Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Crosslinked apo B was shown to resist lysosomal degradation, thereby causing accumulation of oxidized LDL in macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | down-regulates quantity by repression 
translation regulation
|
APOB |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252117 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
Activation of mTORC1 also has dual effects on ApoB synthesis: it inhibits ApoB secretion by decreasing ApoB translation, but promotes ApoB secretion by inhibiting sortilin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MTTP | up-regulates activity 
lipidation
|
APOB |
0.786 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252118 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
As ApoB is translated, it is lipidated by microsomal triglyceride transfer protein (MTP). MTP adds triglycerides to the nascent ApoB during its co-translational translocation into the lumen of the endoplasmic reticulum. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOB | up-regulates
binding
|
LDLR |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11986215 |
In the case of ldl, binding of apolipoprotein b (apob) to the ldl-r18-20 and proteoglycans17 21 initiates plasma clearance and lipoprotein degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBB | up-regulates quantity by stabilization
|
APOB |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251754 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8611031 |
Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Crosslinked apo B was shown to resist lysosomal degradation, thereby causing accumulation of oxidized LDL in macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INS | down-regulates quantity by destabilization
|
APOB |
0.496 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252114 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23721961 |
Insulin decreases ApoB secretion by promoting ApoB degradation in the hepatocyte. Though insulin does not alter ApoB mRNA levels, it inhibits ApoB translation by promoting the trafficking of ApoB mRNA into P-bodies, aggregates of translationally repressed mRNAs |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
APOB
- 
- 