Summary

Name GAPDH
Full Name Glyceraldehyde-3-phosphate dehydrogenase
Synonyms GAPDH, Peptidyl-cysteine S-nitrosylase GAPDH, 2.6.99.- | GAPD
Primary ID P04406
Links - -
Type protein
Relations 5
Pathways Glycolysis and Gluconeogenesis
Function Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GAPDH 0.323
Publications: 1 Organism: Mus Musculus
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates activity img/direct-activation.png phosphorylation GAPDH 0.3
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity img/direct-activation.png transcriptional regulation GAPDH 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification D-glyceraldehyde 3-phosphate(2-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ up-regulates quantity img/direct-activation.png chemical modification 3-phosphonato-D-glyceroyl phosphate(4-) 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis