| + |
GNAI2 | down-regulates 
binding
|
Adenylate_cyclase |
0.615 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267849 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMO | up-regulates activity 
binding
|
GNAI2 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148490 |
|
|
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 16885213 |
Using this assay we determined that mouse Smo couples to all members of the Gi family but does not couple to those of other G protein families. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199162 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23074268 |
it was proposed that Smo might signal through activation of Gi proteins to reduce PKA activity. |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI2 | down-regulates activity
binding
|
ADCY1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256499 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19703466 |
Adenylate cyclase is regulated by stimulatory hormones through Gs(alpha s beta gamma) and inhibitory hormones through Gi(alpha i beta gamma) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
| + |
GNAI2 | up-regulates activity
binding
|
TNFAIP8 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256492 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20607800 |
TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNAI2 | down-regulates
binding
|
ADCY1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37973 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8327893 |
Concentration-dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described. Activated Gi alpha but not G(o) alpha was effective, and myristoylation of Gi alpha was required |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Sonic Hedgehog |
3.0
GNAI2
- 
- 