Summary

Name PRKCG
Full Name Protein kinase C gamma type
Synonyms PKC-gamma | PKCG
Primary ID P05129
Links - -
Type protein
Relations 51
Inhibitors Enzastaurin; bisindolylmaleimide i
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GRIN2B 0.30
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PEBP1 0.40
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation SDC2 0.37
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation EIF4E 0.16
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png phosphorylation GSK3A 0.50
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation DAB2 0.35
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png phosphorylation ANXA1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TOP2A 0.19
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRK2 0.31
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GRK2 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Kidney
+ img/unknown.png phosphorylation STXBP1 0.59
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation STXBP1 0.59
Publications: 1 Organism: Bos Taurus
+ up-regulates activity img/direct-activation.png phosphorylation OCLN 0.24
Publications: 1 Organism: Canis Lupus Familiaris
+ up-regulates activity img/direct-activation.png phosphorylation PSEN1 0.08
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NRGN 0.33
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PA2G4 0.34
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation GJA1 0.23
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation VTN 0.17
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation CYTH2 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation KIR3DL1 0.05
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation TNNI3 0.06
Publications: 2 Organism: Homo Sapiens
Tissue: Muscle
+ up-regulates img/direct-activation.png phosphorylation CHAT 0.19
Publications: 5 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RPS6KB2 0.20
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RAF1 0.27
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ARHGEF7 0.21
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation GRM5 0.30
Publications: 2 Organism: In Vitro
+ up-regulates img/direct-activation.png phosphorylation GRIA4 0.40
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation HSP90AA1 0.14
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation APTX 0.34
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HABP4 0.41
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation CD5 0.21
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation CD5 0.21
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation NOS3
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCG
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PRKCG 0.16
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PRKCG
Publications: 1 Organism: Homo Sapiens