| + |
NFATC3 | up-regulates quantity by expression 
transcriptional regulation
|
IL6 |
0.291 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251732 |
|
|
Homo sapiens |
Smooth Muscle |
| pmid |
sentence |
| 17079331 |
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. |Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF3 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.424 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251721 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 27337441 |
Recent reports show that in mice the microbiome, comprising commensal microorganisms that colonize body surfaces, promotes a partial and low-grade M1-like phenotype in macrophages throughout the body, including those in lymphoid organs (119, 120). This M1-like priming of macrophages induces chromatin remodeling with increased H3K4me3 marks at Ifnb, Il6, and Tnf promoters, which is associated with increased binding of NF-κB p65, IRF3, and Pol II upon cell stimulation |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | COVID-19 Causal Network |
| + |
TNF | up-regulates quantity by expression 
transcriptional regulation
|
IL6 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260856 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32446778 |
Interleukin-6 (IL-6) deserves a more extensive discussion in view of its involvement in the coronavirus-induced cytokine storm. The production of this cytokine is increased by IL-1β and tumor necrosis factor (TNF- α) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
SRF | up-regulates
|
IL6 |
0.288 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255966 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22225874 |
Srf within myofibers modulates Il6 and Cox2/Il4 expressions and, therefore, exerts a paracrine control of satellite cell proliferation and fusion, respectively, which in turn support skeletal muscle hypertrophy. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ANXA1 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.418 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261939 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 27426034 |
Our study demonstrates that ANXA1 can be phosphorylated by PKC and is subsequently translocated to the nucleus of BV-2 microglial cells after OGD/R, resulting in the induction of pro-inflammatory cytokines. we set out to examine the relationship between the different subcellular distributions of ANXA1 and the upregulation of inflammatory cytokines. When BV-2 microglial cells were transfected with ANXA1-S27A constructs following by OGD/R treatment, the pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α, were found to be expressed at lower levels than those of control groups |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL6 | up-regulates activity
binding
|
IL6R |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18923185 |
IL-6 and IL-11 are the only members of the family that signal via the induction of a gp130 homodimer after binding their specific -receptors, IL-6R and IL-11R. When IL-6 binds to the homodimerized IL-6Rα/gp130Rβ, it results in a signaling cascade that is initiated by the autophoshorylation and activation of JAK. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6 | up-regulates
|
Inflammation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260256 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18231581 |
Induction and over-production of proinflammatory cytokines and chemokines, such as IL-6, IL-8, TNF-a and INF-c, were considered to be main mediators in the pathogenesis of SARS |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM |
| + |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.488 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255969 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 24737129 |
We have identified a novel role for p53 that is specific to the regulation of several pro-inflammatory genes in human macrophages, including IL-6, IL-8 and CXCL1. Importantly, NF-κB co-activation is essential for this regulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFATC2 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.417 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251731 |
|
|
Homo sapiens |
Smooth Muscle |
| pmid |
sentence |
| 17079331 |
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. |Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
A9/b1 integrin | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253313 |
|
|
Homo sapiens |
Synovial Fibroblast |
| pmid |
sentence |
| 24241034 |
Importantly, autocrine and paracrine interactions of α9β1 integrin and tenascin-C induced the expression of MMPs and IL-6 in synovial fibroblasts, as well as TNF-α and IL-1β in synovial macrophages. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Calcineurin | up-regulates quantity by expression
|
IL6 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252340 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PPP3CB | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251734 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AP1 | up-regulates
transcriptional regulation
|
IL6 |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254513 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20086235 |
JNK phosphorylates proteins that are part of AP-1, in particular c-Jun and activating transcription factor 2 (ATF-2). With dominant-negative mutants, antisense RNA, inhibitors, and genetic ablation, it has been shown that JNK and c-Jun play a major role in IL-1–induced expression of genes encoding IL-6 and IL-8 and other IL-1–responsive genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM |
| + |
IL6 | up-regulates
binding
|
IL6R |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202030 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23663276 |
In classical il-6 signaling, the cytokine first binds to the membrane-bound il-6 receptor (il-6r;cd126) that is induced to associate with a homodimer of gp130 which then transmits the intracellular signal. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42866 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 8676083 |
We first observed that cultured mouse embryonic dorsal root ganglia exhibited dramatic neurite extension by simultaneous addition of il-6 and soluble il-6r (sil-6r), a complex that is known to interact with and activate a signal transducing receptor component, gp130 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137236 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15895091 |
We show that the augmentation of the il6 signal by recombinant il6 receptors (ril6r) delivery allows the functional recovery of phagocytes in a peritonitis mouse model. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Brain |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6 | up-regulates activity
|
STAT3 |
0.75 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255415 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23869758 |
IL-6 induced dose-dependent increase in satellite cell proliferation by activating the JAK2/STAT3/cyclin D1 pathway.Treatment with 1 ng/ml IL-6 for 3 h significantly increased p-STAT3+/MyoD+ cell numbers by 44% compared to control media only . |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Skeletal Muscle |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL1B | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.537 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260855 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32446778 |
Interleukin-6 (IL-6) deserves a more extensive discussion in view of its involvement in the coronavirus-induced cytokine storm. The production of this cytokine is increased by IL-1β and tumor necrosis factor (TNF- α) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
TLR5 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24709011 |
These studies demonstrate a novel function of Toll-like receptor-5 (TLR5) in a human multiple myeloma (MM) cell line, KMS28BM. These cells express high levels of both TLR5 mRNA and protein. When cells were treated with the specific TLR5 ligand flagellin, proliferation was increased, and the secretion of IgG λ antibody and the expression of the pro-inflammatory cytokine IL-6 were increased via NF-κB activation through PI3K/AKT and p38 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF2 | up-regulates
transcriptional regulation
|
IL6 |
0.307 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254512 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20086235 |
JNK phosphorylates proteins that are part of AP-1, in particular c-Jun and activating transcription factor 2 (ATF-2). With dominant-negative mutants, antisense RNA, inhibitors, and genetic ablation, it has been shown that JNK and c-Jun play a major role in IL-1–induced expression of genes encoding IL-6 and IL-8 and other IL-1–responsive genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION |
| + |
IL6 | up-regulates
|
AMPK |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255338 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 23531613 |
AMPK phosphorylation was increased nearly fourfold (Fig. 2C) with the high dose of IL-6 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
Degranulation | up-regulates quantity
|
IL6 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255349 |
|
|
Homo sapiens |
Mast Cell |
| pmid |
sentence |
| 24232182 |
Particularly, damage-activated mast cells almost instantly begin to secrete TNFa, histamine and tryptase and then initiate the de novo synthesis of other cytokines, such as interleukin (IL)6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255357 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20219869 |
Once in the nucleus, NF-kB can induce the transcription of iNOS, TNF-alpha, and IL-1, which may then promote further NF-kB activation, as well as elevate the expression of other inflammatory mediators such as CCL2 and IL-6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
RELA | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.682 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266088 |
|
|
Homo sapiens |
A-549 Cell |
| pmid |
sentence |
| 17350185 |
The IL-6 promoter was stimulated by NF-kB RelA protein. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251737 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 27337441 |
Recent reports show that in mice the microbiome, comprising commensal microorganisms that colonize body surfaces, promotes a partial and low-grade M1-like phenotype in macrophages throughout the body, including those in lymphoid organs (119, 120). This M1-like priming of macrophages induces chromatin remodeling with increased H3K4me3 marks at Ifnb, Il6, and Tnf promoters, which is associated with increased binding of NF-κB p65, IRF3, and Pol II upon cell stimulation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
PP2B | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269987 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL6 | up-regulates activity
|
IL6ST |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-238617 |
|
|
in vitro |
|
| pmid |
sentence |
| 8511589 |
The biological functions of interleukin-6 (IL-6) are mediated through a signal-transducing component of the IL-6 receptor, gp130, which is associated with the ligand-occupied IL-6 receptor (IL-6R) protein. Binding of IL-6 to IL-6R induced disulfide-linked homodimerization of gp130. Tyrosine kinase activity was associated with dimerized but not monomeric gp130 protein. Substitution of serine for proline residues 656 and 658 in the cytoplasmic motif abolished tyrosine kinase activation and cellular responses but not homodimerization of gp130. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
NFATC1 | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251730 |
|
|
Homo sapiens |
Smooth Muscle |
| pmid |
sentence |
| 17079331 |
The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway has been found to play a role in regulating growth and differentiation in several cell types. However, the functional significance of NFAT in the vasculature is largely unclear. Here we show that NFATc1, NFATc3, and NFATc4 are expressed in human myometrial arteries. |Chronic inhibition of NFAT significantly reduced IL-6 production in intact myometrial arteries and inhibited cell proliferation in vascular smooth muscle cells cultured from explants from the same arteries. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL6 | up-regulates activity
binding
|
IL6ST |
0.862 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-48041 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 15895091 |
A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (il-6) and its a-receptor (il-6ralpha) revealed a hexameric architecture in which the gp130 membrane-distal regions were approximately 100 a apart, in contrast to the close apposition seen between short cytokine receptor complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
S | up-regulates quantity
|
IL6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260278 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 17412287 |
The ability of S-protein to induce TNF-a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV CYTOKINE STORM |
| + |
PPP3CC | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251735 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
NfKb-p65/p50 | up-regulates
transcriptional regulation
|
IL6 |
0.622 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254511 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20086235 |
Both NF-κBs bind to a conserved DNA motif (80) that is found in numerous IL-1–responsive genes, in particular the ones encoding IκBα (81), IL-6 (82), IL-8 (18, 83,84), monocyte chemoattractant protein 1 (MCP1) (28), and cyclooxygenase 2 (COX2) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL6 | down-regulates quantity by repression 
transcriptional regulation
|
GCH1 |
0.27 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252220 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12859689 |
CT-1 exerted these effects by decreasing tyrosine hydroxylase, GTP cyclohydrolase (GCH) and NE transporter mRNAs, while IL-6 lowered only GCH mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP3CA | up-regulates quantity by expression
transcriptional regulation
|
IL6 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251733 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18177723 |
Interestingly, since IL-6 production by nerve-mediated skeletal muscle contraction has recently been shown to be partly dependent on the activation of the calcineurin pathway |The fact that IL-6 is produced not only by proliferating satellite cells but also by growing myofibers during hypertrophy |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
chloroquine | down-regulates quantity
|
IL6 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260854 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32283152 |
Chloroquine inhibits the production and release of TNF and IL-6, which indicates that chloroquine may suppress the cytokine storm in patients infected with COVID-19. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | COVID-19 Causal Network, SARS-CoV CYTOKINE STORM |
3.0
IL6
- 
- 