Summary

Name IL6
Full Name Interleukin-6
Synonyms IL-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2 | IFNB2
Primary ID P05231
Links - -
Type protein
Relations 35
Pathways COVID-19 Causal Network, IL6 Signaling, Macrophage: IL6, Macrophage: Polarization and myogenesis, Multiple sclerosis, Myoblast: IL6 and hypertrophy, Myofiber: IL6 and atrophy, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM, Satellite: IL6, T-Lymphocyte: IL6
Function Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).

Viewer

Relations

Regulator Mechanism target score
+ up-regulates quantity img/indirect-activation.png IL6 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/direct-activation.png binding IL6ST 0.863
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png IL6 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.681
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png binding IL6R 0.916
Publications: 3 Organism: Homo Sapiens
Tissue: Brain, Muscle, Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.2
Publications: 1 Organism: Mus Musculus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation GCH1 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/indirect_inhibition.png IL6 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.423
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network
+ up-regulates img/indirect-activation.png AMPK 0.249
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.528
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.622
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.417
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.254
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding IL6R 0.916
Publications: 1 Organism: Homo Sapiens
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png Inflammation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM
+ up-regulates activity img/indirect-activation.png STAT3 0.749
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.535
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.416
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.369
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png IL6 0.257
Publications: 1 Organism: Mus Musculus
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.629
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV MAPK PERTURBATION, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.487
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png transcriptional regulation IL6 0.306
Publications: 1 Organism: Homo Sapiens
Pathways:COVID-19 Causal Network, SARS-CoV MAPK PERTURBATION
+ up-regulates quantity img/indirect-activation.png IL6 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.622
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:COVID-19 Causal Network, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IL6 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/indirect-activation.png IL6ST 0.863
Publications: 1 Organism: In Vitro
Pathways:IL6 Signaling, Multiple sclerosis, SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.29
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation IL6 0.432
Publications: 1 Organism: Homo Sapiens