Summary

Name EDN1
Full Name Endothelin-1
Synonyms Preproendothelin-1, PPET1
Primary ID P05305
Links - -
Type protein
Relations 9
Function Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage EDN1 0.489
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EDNRB 0.945
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png EDN1 0.266
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EDNRA 0.878
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MC1R 0.36
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation EDN1 0.283
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png EDN1 0.281
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png EDN1 0.7
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYH7 0.286
Publications: 1 Organism: Homo Sapiens