| + |
AL/b2 integrin | up-regulates activity 
binding
|
ICAM1 |
0.829 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253364 |
|
|
Mus musculus |
Pro-B-lymphocyte |
| pmid |
sentence |
| 12808052 |
The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration|Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TWIST2 | up-regulates quantity by expression 
transcriptional regulation
|
ICAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255514 |
|
|
Homo sapiens |
HEY Cell |
| pmid |
sentence |
| 17487558 |
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITGAM | up-regulates
binding
|
ICAM1 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255041 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Before leaving the vessel lumen, neutrophils crawl on the endothelium, primarily using cell surface Mac-1 integrins binding to endothelial ICAM-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ICAM1 | up-regulates
|
Chemotaxis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255042 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23994464 |
Before leaving the vessel lumen, neutrophils crawl on the endothelium, primarily using cell surface Mac-1 integrins binding to endothelial ICAM-1. After finding the place for transmigration, neutrophils migrate to the interstitium through transcellular or paracellular routes and begin chemotaxing towards the site of infection/inflammation within the perivascular and interstitial space. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FEV | down-regulates quantity by repression 
transcriptional regulation
|
ICAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-101246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12761502 |
Fev acts as a transcriptional repressor through its dna-binding ets domain and alanine-rich domain. / we show here that fev dramatically represses both basal and ectopically ets-activated transcription driven by the icam-1 promoter, and that the effect is dose dependent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | down-regulates quantity by repression
transcriptional regulation
|
ICAM1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253917 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22235125 |
It has been shown that ERG is a positive regulator of several EC-restricted genes including VE-cadherin, endoglin, and von Willebrand factor, and a negative regulator of other genes such as interleukin (IL)-8 and intercellular adhesion molecule (ICAM)-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ITGAL | up-regulates
binding
|
ICAM1 |
0.919 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255040 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 23994464 |
This leads to further neutrophil-endothelial cell interactions through the binding of LFA-1 to its endothelial counterreceptor ICAM-1 during the slow rolling phase |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ICAM1 | up-regulates
binding
|
ITGAX |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-31388 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7679388 |
Using assays to quantify cd11c-mediated cell adhesion, we demonstrate that cd11c recognizes icam-2 and vcam-1. The cd11c-binding site on vcam-1 appears to be different from that used by the integrin alpha4. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TWIST1 | up-regulates quantity by expression
transcriptional regulation
|
ICAM1 |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255515 |
|
|
Homo sapiens |
HEY Cell |
| pmid |
sentence |
| 17487558 |
Immunoblot analysis showed that HEY/si-TWIST cells exhibited decreased expression levels of CD29, CD44 and CD54 compared to those of HEY/si-scrambled cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ICAM1
- 
- 