| + |
CRH | up-regulates quantity by expression 
transcriptional regulation
|
KRT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251882 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15787816 |
CRH also increased AP-1 binding activity, cell granularity, cytokeratin 1 and involucrin expression, and inhibited cytokeratin 14 expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MECP2 | down-regulates quantity by repression 
transcriptional regulation
|
CRH |
0.489 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264548 |
|
|
Mus musculus |
Brain |
| pmid |
sentence |
| 17108082 |
Collectively, these results point to a specific association between WT MeCP2 and the methylated promoter region of Crh in vivo. In contrast, the MeCP2308 protein was not detected at the Crh promoter. | Thus, the results of seqChIP indicate that MeCP2 preferentially associates with a transcriptionally inactive, dimethyl-histone H3 Lys-9-rich form of the Crh promoter in mice. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
AR | down-regulates quantity by repression
transcriptional regulation
|
CRH |
0.314 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268723 |
|
|
Homo sapiens |
Neuroblastoma Cell |
| pmid |
sentence |
| 16446741 |
A direct androgenic involvement in the expression of human corticotropin-releasing hormone|A potential androgen-responsive element (ARE) in the human CRH promoter was subsequently analyzed with bandshifts and cotransfections in neuroblastoma cells. In the presence of testosterone, recombinant human AR bound specifically to the CRH-ARE. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRH | up-regulates 
binding
|
CRHR1 |
0.957 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108713 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11416224 |
Crf and ucn bind and activate crf-r1 with similarly high affinities. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRH | up-regulates activity
binding
|
CRHR2 |
0.916 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23504413 |
The actions of CRH are transduced through CRH receptors, which belong to the class II/secretin-like family of the G-protein coupled receptor (GPCR) superfamily (Martin et al. 2005). There are three types of CRH receptors – type 1 (CRHR1), type 2 (CRHR2) and type 3 (CRHR3). Among these, CRHR3 has not been identified in mammals. |CRH is a high-affinity ligand of CRHR1. It also binds to CRHR2, but with lower affinity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRH | down-regulates quantity by repression
transcriptional regulation
|
KRT14 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251899 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15468147 |
CRH stimulated the expression of cytokeratin 1 and involucrin, and inhibited cytokeratin 14 on both mRNA and protein levels. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ESR1 | up-regulates quantity by expression
transcriptional regulation
|
CRH |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268721 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8408641 |
Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.|Gel retardation and immunoprecipitation demonstrated specific association between the perfect half-palindromic EREs of hCRH gene and the DNA binding domain of hER in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypothalamus |
| + |
ESR2 | up-regulates quantity by expression
transcriptional regulation
|
CRH |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8408641 |
Evidence of direct estrogenic regulation of human corticotropin-releasing hormone gene expression. Potential implications for the sexual dimophism of the stress response and immune/inflammatory reaction.|Gel retardation and immunoprecipitation demonstrated specific association between the perfect half-palindromic EREs of hCRH gene and the DNA binding domain of hER in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypothalamus |
3.0
CRH
- 
- 