| + |
TPO | down-regulates quantity 
chemical modification
|
L-tyrosine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266956 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity 
chemical modification
|
3,5-diiodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267030 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity
chemical modification
|
L-alanine zwitterion |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267041 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
NKX2-1 | up-regulates quantity by expression
transcriptional regulation
|
TPO |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267278 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
TSH regulates TPO expression through the cAMP pathway and acts with thyroid-specific transcription factors such as TTF-1, TTF-2 and Pax-8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
bisphenol A | down-regulates activity
chemical inhibition
|
TPO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268786 |
|
|
in vitro |
|
| pmid |
sentence |
| 17379648 |
Half-maximal inhibition of TPO by BPA and F21388 occurred at 174 and 37.5 mol/liter in the guaiacol assay. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
TPO | up-regulates quantity
chemical modification
|
diiodine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
TPO is considered the key enzyme in thyroid hormonogenesis. It catalyzes the oxidation of iodide that is necessary for the iodinationof the TG tyrosyl residues (the organification reaction). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX8 | up-regulates quantity by expression
transcriptional regulation
|
TPO |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267277 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
TSH regulates TPO expression through the cAMP pathway and acts with thyroid-specific transcription factors such as TTF-1, TTF-2 and Pax-8. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity
chemical modification
|
3-iodo-L-tyrosine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16098474 |
TPO plays a key role in thyroid hormone synthesis by catalyzing both the iodination of tyrosine residues to form monoiodotyrosine (MIT) and diiodotyrosine (DIT) residues. The first step in the process of thyroid hormone synthesis is the binding of iodine to tyrosine residues in Tg, which yields MIT and DIT residues. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
TPO | up-regulates quantity
chemical modification
|
3,3',5'-triiodothyronine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267039 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
FOXE1 | up-regulates quantity by expression
transcriptional regulation
|
TPO |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267279 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27347897 |
TSH regulates TPO expression through the cAMP pathway and acts with thyroid-specific transcription factors such as TTF-1, TTF-2 and Pax-8 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Hypophysis |
| + |
TPO | up-regulates quantity
chemical modification
|
L-thyroxine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267040 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28153798 |
The synthesis of T3 and T4 is achieved through the transfer of an iodophenoxyl group from a MIT or DIT residue called a “donor” onto a DIT residue called an “acceptor”. TPO seems to be primarily responsible for catalyzing the oxidations of iodotyrosines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
| + |
iodide | up-regulates activity
chemical activation
|
TPO |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268139 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, Iodide is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Follicle |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
| + |
TPO | up-regulates activity
catalytic activity
|
TG |
0.528 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259914 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23349248 |
After transport through the apical membrane, I− is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid cancer, Thyroid Hormone Metabolism |
3.0
TPO
- 
- 