Summary

Name CAPN1
Full Name Calpain-1 catalytic subunit
Synonyms Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP | CANPL1
Primary ID P07384
Links - -
Type protein
Relations 10
Pathways Alzheimer
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png cleavage F2R 0.383
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2R 0.383
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png cleavage F2RL1 0.301
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png cleavage GSK3A 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.303
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png cleavage MAPT 0.344
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage CDK5R1 0.548
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png cleavage CDK5/CDK5R1 0.556
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ down-regulates activity img/direct_inhibition.png binding CAPN1 0.913
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer
+ up-regulates activity img/direct-activation.png chemical activation CAPN1 0.8
Publications: 1 Organism: Homo Sapiens