| + |
NFIL3 | up-regulates quantity by expression 
transcriptional regulation
|
IL3 |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266222 |
|
|
Hylobates lar |
|
| pmid |
sentence |
| 7565758 |
NF-IL3A transactivates the IL-3 promoter through the A region sequences. |
|
| Publications: |
1 |
Organism: |
Hylobates Lar |
| + |
IL3 | up-regulates 
|
NFIL3 |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242763 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10082541 |
We previously reported that NFIL3 is an IL-3-responsive gene in Baf-3 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL3 | up-regulates
binding
|
IL3RA |
0.883 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11700046 |
The results demonstrate that both the association and dissociation rates for the binding of il-3 to the il-3ralpha are altered by truncation and by amino acid substitution at individual sites. Intracellular signaling studies using k116w and e43n demonstrate that differences in the il-3alpha binding characteristics are reflected in magnitude and kinetics of stat5 phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1465408 |
These results show the generation of an il-3 analog with increased biological and binding activities and support a model where the c terminus of il-3 interacts with the alpha chain of the il-3 receptor, making this region a useful focus for the development of more potent il-3 agonists or antagonists |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
IL3
- 
- 