Summary

Name HTR1A
Full Name 5-hydroxytryptamine receptor 1A
Synonyms 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A | ADRB2RL1, ADRBRL1
Primary ID P08908
Links - -
Type protein
Relations 83
Inhibitors spiperone; methiothepin; haloperidol; N-tert-butyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-phenylpropanamide; N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide; pindolol; LSM-20934; pipamperone; sertindole; 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; zotepine; tertatolol; paliperidone; risperidone; pimozide; 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione; 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide; thioridazine; propranolol; Tiospirone; chlorpromazine; NAN 190
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation HTR1A 0.275
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAO1 0.432
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus, Rattus Norvegicus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HTR1A 0.384
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAI1 0.468
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus, Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates activity img/direct-activation.png binding GNAI3 0.545
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Rattus Norvegicus, Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Longicaudatus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus, Rattus Norvegicus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HTR1A 0.456
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus, Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 3 Organism: Cricetulus Griseus, Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Rattus Norvegicus
Tissue: Hippocampus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 2 Organism: Rattus Norvegicus, Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding GNAQ 0.306
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation HTR1A 0.456
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Rattus Norvegicus, Cricetulus Griseus
+ up-regulates activity img/direct-activation.png relocalization HTR1A 0.415
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 2 Organism: Cricetulus Griseus, Rattus Norvegicus
Tissue: Hippocampus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png chemical activation HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1A 0.8
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation HTR1A 0.345
Publications: 1 Organism: Homo Sapiens