| + |
SMO | up-regulates 
binding
|
CXCL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148484 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
We found that smo, by virtue of what appears to be constitutive activity, activates all members of the g(i) family but does not activate members of the g(s), g(q), and g(12) families. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates quantity by expression 
transcriptional regulation
|
GLI3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
The data suggest that smo is in fact the source of two signals relevant to the activation of gli: one involving g(i) and the other involving events at smo's c-tail independent of g(i). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates
|
GLI1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
The data suggest that smo is in fact the source of two signals relevant to the activation of gli: one involving g(i) and the other involving events at smo's c-tail independent of g(i). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FZD3 | up-regulates
binding
|
CXCL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152597 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor gpcrs signal through four relatively small families of galfa proteins (galfas, galfai/o, galfaq, and galfa12/13), and if fzd receptors are classic gpcrs, they should signal through one of these four galfa families. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14977528 |
In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor gpcrs signal through four relatively small families of galfa proteins (galfas, galfai/o, galfaq, and galfa12/13), and if fzd receptors are classic gpcrs, they should signal through one of these four galfa families. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CEBPD | up-regulates quantity by expression
transcriptional regulation
|
CXCL1 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254060 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 23028973 |
CEBPD activated in macrophages played a functional role in promoting the tube formation of endothelial cells and the migration and proliferation of synoviocytes. In vivo DNA binding assays and reporter assays showed that CEBPD up-regulated CCL20, CXCL1, IL23A and TNFAIP6 transcripts through direct binding to their promoter regions. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MTA1 | up-regulates quantity by expression
transcriptional regulation
|
CXCL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254598 |
|
|
Homo sapiens |
OVCAR-3 Cell |
| pmid |
sentence |
| 18719363 |
Screening for the expression of angiogenic cytokines expressed by ovarian cancer cells revealed MTA1-mediated upregulation of the oncogenic and angiogenic cytokine GRO (growth-regulated oncogene, CXCL1). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates quantity by expression
transcriptional regulation
|
GLI2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148457 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
The data suggest that smo is in fact the source of two signals relevant to the activation of gli: one involving g(i) and the other involving events at smo's c-tail independent of g(i). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | down-regulates 
binding
|
PRKACA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152594 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
As pka suppresses the activity of gli, smo might use the stimulation of pi3k by galfai and gbetagamma subu- nits to block pka in cells that have high levels of camp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates
binding
|
PLCE1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-152591 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17251915 |
In the non-canonical wnt pathway, frizzled uses galfaq or galfai and gbetagamma dimers to activate phospholipase c (plc), resulting in protein kinase c (pkc) activation and calcium mobilization that regulates the transcription factor nfat, and frizzled also signals through the small gtpases rho and rac to c-jun n-terminal kinase (jnk), which activates the ap1 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cyclopamine | down-regulates
chemical inhibition
|
CXCL1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-148469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16885213 |
Cyclopamine and other inhibitors of hh signaling were found to inhibit smo coupling to gi in a manner consistent with inverse agonism. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CXCL1
- 
- 