| + |
LY96 | up-regulates activity 
binding
|
HMGB1 |
0.612 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252058 |
|
|
Mus musculus |
Macrophage |
| pmid |
sentence |
| 25559892 |
Here we demonstrate that the extracellular TLR4 adaptor, myeloid differentiation factor 2 (MD-2), binds specifically to the cytokine-inducing disulfide isoform of HMGB1, to the exclusion of other isoforms. Using MD-2-deficient mice, as well as MD-2 silencing in macrophages, we show a requirement for HMGB1-dependent TLR4 signaling. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HMGB1 | up-regulates activity
binding
|
HOXC6 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219937 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HMGB1 | up-regulates activity
binding
|
AGER |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252059 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25014009 |
HMGB1 is known to influence cellular responses within the nervous system via two distinct receptor families; the Receptor for Advanced Glycation End-products (RAGE) and Toll-like receptors (TLRs) |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HMGB1 | up-regulates activity
binding
|
HOXD3 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219980 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HMGB1 | up-regulates quantity by expression 
transcriptional regulation
|
IL2RA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240113 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 7862168 |
The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli. Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified. We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y). Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated. Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGB1 | up-regulates activity
binding
|
TLR4 |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252057 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20547845 |
Here we show that Toll-like receptor 4 (TLR4), a pivotal receptor for activation of innate immunity and cytokine release, is required for HMGB1-dependent activation of macrophage TNF release. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMGB1 | up-regulates activity
binding
|
HOXD10 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240556 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HMGB1 | up-regulates activity
binding
|
HOXD9 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236956 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HMGB1 | up-regulates activity
binding
|
HOXB3 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219902 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HMGB1 | up-regulates activity
binding
|
HOXB1 |
0.3 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219853 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
HMGB1 | up-regulates activity
binding
|
HOXD11 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-240559 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
HMGB1
- 
- 