Summary

Name CXCL8
Full Name Interleukin-8
Synonyms IL-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8, Emoctakin, Granulocyte chemotactic protein 1, GCP-1, Monocyte-derived neutrophil chemotactic factor, MDNCF, Monocyte-derived neutrophil-activating peptide, MONAP, Neutrophil-activating protein 1, NAP-1, Protein 3-10C, T-cell chemotactic factor | IL8
Primary ID P10145
Links - -
Type protein
Relations 11
Pathways SARS-CoV CYTOKINE STORM
Function IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.

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Relations

Regulator Mechanism target score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CXCL8 0.631
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png Angiogenesis 0.7
Publications: 1
+ up-regulates img/direct-activation.png binding CXCR1 0.769
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CXCL8 0.242
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Inflammation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates img/direct-activation.png binding CXCR2 0.855
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CXCL8 0.559
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates img/indirect-activation.png ARDS 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates quantity img/indirect-activation.png CXCL8 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:SARS-CoV CYTOKINE STORM
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CXCL8 0.484
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CXCL8 0.2
Publications: 1 Organism: Homo Sapiens