Summary

Name RARB
Full Name Retinoic acid receptor beta
Synonyms RAR-beta, HBV-activated protein, Nuclear receptor subfamily 1 group B member 2, RAR-epsilon | HAP, NR1B2
Primary ID P10826
Links - -
Type protein
Relations 20
Pathways Oxytocin signaling, Retinoic acid Signaling
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (PubMed:12554770). The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element (PubMed:29021580). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png chemical activation RARB 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Epidermis
+ up-regulates activity img/direct-activation.png chemical activation RARB 0.8
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates img/direct-activation.png binding RXRB 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.386
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates img/direct-activation.png binding RARB 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding RARB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THR 0.393
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation RARB 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding THR 0.393
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding THRA 0.386
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates quantity by expression img/indirect-activation.png RARB 0.299
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RXRA 0.66
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation OXT 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Oxytocin signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARB 0.644
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RARB 0.66
Publications: 1 Organism: Homo Sapiens
Pathways:Retinoic acid Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RARB 0.433
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation RARB 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png chemical activation RARB 0.8
Publications: 1 Organism: Homo Sapiens