Summary

Name MYL2
Full Name Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Synonyms MLC-2, MLC-2v, Cardiac myosin light chain 2, Myosin light chain 2, slow skeletal/ventricular muscle isoform, MLC-2s/v, Ventricular myosin light chain 2 | MLC2
Primary ID P10916
Links - -
Type protein
Relations 2
Function Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation MYL2 0.632
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MYL2 0.606
Publications: 1 Organism: Rattus Norvegicus