| + |
PCSK2 | up-regulates activity 
cleavage
|
IAPP |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261791 |
Arg33 |
ESHQVEKrKCNTATC |
in vitro |
|
| pmid |
sentence |
| 10931181 |
The processing of proinsulin to insulin occurs in the secretory granules at the C-terminal end of pairs of basic amino acids, Arg31-Arg32 and Lys64-Arg65 [9,10]. Following cleavage, by the prohormone convertases, PC3 (also known as PC1) and PC2, the pair of basic amino acids are removed rapidly by carboxypeptidase E (CPE) to produce the mature insulin molecule |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PCSK1 | up-regulates activity
cleavage
|
IAPP |
0.461 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261782 |
Lys72 |
VGSNTYGkRNAVEVL |
in vitro |
|
| pmid |
sentence |
| 10931181 |
The processing of proinsulin to insulin occurs in the secretory granules at the C-terminal end of pairs of basic amino acids, Arg31-Arg32 and Lys64-Arg65 [9,10]. Following cleavage, by the prohormone convertases, PC3 (also known as PC1) and PC2, the pair of basic amino acids are removed rapidly by carboxypeptidase E (CPE) to produce the mature insulin molecule |
|
| Publications: |
1 |
Organism: |
In Vitro |
3.0
IAPP
- 
- 