Summary

Name ANPEP
Full Name Aminopeptidase N
Synonyms AP-N, hAPN, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150 | APN, CD13, PEPN
Primary ID P15144
Links - -
Type protein
Relations 2
Inhibitors Tosedostat
Function Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition ANPEP 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ANPEP 0.2
Publications: 1 Organism: Homo Sapiens