Summary

Name TNFRSF1A
Full Name Tumor necrosis factor receptor superfamily member 1A
Synonyms Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60 | TNFAR, TNFR1
Primary ID P19438
Links - -
Type protein
Relations 20
Pathways Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Macrophage: Polarization and myogenesis, Macrophage: TNF alpha, Mitochondrial Control of Apoptosis, Multiple sclerosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SARS-COV APOPTOSIS, Satellite: TNFA, TNF-alpha Signaling, Tnfa_Notch_crosstalk
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation TNFRSF1A 0.518
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding TNFRSF1A 0.27
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding TNFRSF1A 0.511
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRADD 0.799
Publications: 3 Organism: Homo Sapiens, Mus Musculus
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, NF-KB Canonical, P38 Signaling, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ down-regulates quantity by destabilization img/indirect_inhibition.png NFKBIA 0.538
Publications: 1 Organism: Mus Musculus
Pathways:COVID-19 Causal Network, Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, TNF-alpha Signaling
+ up-regulates activity img/indirect-activation.png MAPK14 0.384
Publications: 2
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates activity img/direct-activation.png binding TNFRSF1A 0.923
Publications: 6 Organism: Homo Sapiens
Pathways:Alzheimer, COVID-19 Causal Network, Death Receptor Signaling, Inhibition of Apoptosis, Mitochondrial Control of Apoptosis, Multiple sclerosis, NF-KB Canonical, P38 Signaling, P38 Signaling and Myogenesis, SARS-COV APOPTOSIS, TNF-alpha Signaling
+ down-regulates activity img/direct_inhibition.png binding TNFRSF1A 0.629
Publications: 1 Organism: Mus Musculus
Pathways:TNF-alpha Signaling
+ up-regulates img/indirect-activation.png MAPK14 0.384
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:P38 Signaling, P38 Signaling and Myogenesis, TNF-alpha Signaling
+ up-regulates img/direct-activation.png TRAF2 0.826
Publications: 1 Organism: Homo Sapiens
Pathways:Inhibition of Apoptosis, Multiple sclerosis, NF-KB Canonical, P38 Signaling, TNF-alpha Signaling