3.0
Summary
| Name |  ATP2B1View Modifications |
| Full Name | Plasma membrane calcium-transporting ATPase 1 |
| Synonyms | PMCA1, Plasma membrane calcium ATPase isoform 1, Plasma membrane calcium pump isoform 1 | PMCA1 |
| Primary ID | P20020 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity). Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511). |
phosphorylation