Summary

Name TNFRSF1B
Full Name Tumor necrosis factor receptor superfamily member 1B
Synonyms Tumor necrosis factor receptor 2, TNF-R2, Tumor necrosis factor receptor type II, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor | TNFBR, TNFR2
Primary ID P20333
Links - -
Type protein
Relations 10
Pathways SAPK/JNK Signaling
Function Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png TRAF1 0.708
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ up-regulates activity img/indirect-activation.png MAPK14 0.303
Publications: 2
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TNFRSF1B 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TNFRSF1B 0.928
Publications: 3 Organism: , Homo Sapiens
+ up-regulates img/direct-activation.png binding TRAF1 0.708
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling
+ down-regulates quantity by destabilization img/direct_inhibition.png binding TNFRSF1B 0.406
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding TRAF2 0.696
Publications: 1 Organism: Homo Sapiens
Pathways:SAPK/JNK Signaling