| + |
MAOA | up-regulates quantity 
chemical modification
|
3,4-dihydroxyphenylacetaldehyde |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264003 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |It undergoes oxidative deamination, catalyzed by the enzyme monoamine oxidase (MAO) in the presence of flavin adenine dinucleotide (FAD), to produce reactive aldehyde 3,4-dihydroxyphenylacetaldehyde (DOPAL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
MAOA | down-regulates quantity 
chemical modification
|
3-methoxytyramine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263999 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
MAOA | up-regulates quantity
chemical modification
|
(R)-noradrenaline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269745 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20493079 |
The selective monoamine oxidase inhibitors clorgyline and (−)-deprenyl were used to study the distribution of monoamine oxidase-A and -B (MAO-A, MAO-B) activities towards (−)-noradrenaline and (+),(−)-adrenaline in homogenates from seven different regions of human brain. Noradreanline and adrenaline were substrates for both forms of the enzyme in all regions studied. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
moclobemide | down-regulates activity
chemical inhibition
|
MAOA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258314 |
|
|
in vitro |
|
| pmid |
sentence |
| 21680183 |
Twenty-two pyrazoline derivatives were synthesized and tested for their human MAO (hMAO) inhibitory activity. Twelve molecules with unsubstituted ring A and substituted ring C (5–16) were found to be potent inhibitors of hMAO-A isoform with SIMAO-A in the order 103 and 104. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAOA | up-regulates quantity
chemical modification
|
(R)-adrenaline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269744 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20493079 |
The selective monoamine oxidase inhibitors clorgyline and (−)-deprenyl were used to study the distribution of monoamine oxidase-A and -B (MAO-A, MAO-B) activities towards (−)-noradrenaline and (+),(−)-adrenaline in homogenates from seven different regions of human brain. Noradreanline and adrenaline were substrates for both forms of the enzyme in all regions studied. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
MAOA | down-regulates quantity
chemical modification
|
dopamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264001 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |It undergoes oxidative deamination, catalyzed by the enzyme monoamine oxidase (MAO) in the presence of flavin adenine dinucleotide (FAD), to produce reactive aldehyde 3,4-dihydroxyphenylacetaldehyde (DOPAL). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
| + |
NHLH2 | up-regulates quantity by expression 
transcriptional regulation
|
MAOA |
0.415 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254829 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 22169038 |
SIRT1 deacetylates the brain-specific helix-loop-helix transcription factor NHLH2 on lysine 49 to increase its activation of the MAO-A promoter |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| + |
Phenelzine | down-regulates activity
chemical inhibition
|
MAOA |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257777 |
|
|
in vitro |
|
| pmid |
sentence |
| 18426226 |
Phenylethylhydrazine stoichiometrically reduces the covalent FAD moieties of MAO A and of MAO B. Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAOA | down-regulates quantity
chemical modification
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264014 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Catecholamine metabolism |
3.0
MAOA
- 
- 