Summary

Name FPR1
Full Name fMet-Leu-Phe receptor
Synonyms fMLP receptor, N-formyl peptide receptor, FPR, N-formylpeptide chemoattractant receptor
Primary ID P21462
Links - -
Type protein
Relations 13
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation FPR1 0.15
Publications: 13 Organism: In Vitro