+ |
CXCL8 | up-regulates
binding
|
CXCR2 |
0.856 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-107983 |
|
|
Homo sapiens |
|
pmid |
sentence |
11350788 |
Il-8 activates both the cxcr1 and the cxcr2 on microvascular endothelial cells, using different signal transduction cascades. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
CXCR2 |
0.269 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271682 |
|
|
|
|
pmid |
sentence |
18292390 |
EMSA, ChIP, and transient transfection assays indicate that PPAR-gamma activates the CXCR2 promoter by binding to a PPAR response element (PPRE). |
|
Publications: |
1 |
+ |
GRK2 | down-regulates activity
phosphorylation
|
CXCR2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260647 |
|
|
Mus musculus |
Lung |
pmid |
sentence |
22634615 |
Upon activation, GRK2 phosphorylates CXCR2 and causes receptor desensitization and internalization, leading to down-regulation of neutrophil chemotaxis |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
MIF | up-regulates activity
binding
|
CXCR2 |
0.397 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252061 |
|
|
Mus musculus |
|
pmid |
sentence |
17435771 |
We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
Pathways: | Toll like receptors |