Summary

Name ITGA3
Full Name Integrin alpha-3
Synonyms CD49 antigen-like family member C, FRP-2, Galactoprotein B3, GAPB3, VLA-3 subunit alpha | MSK18
Primary ID P26006
Links - -
Type protein
Relations 3
Function Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding A3/b1 integrin 0.796
Publications: 1
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ITGA3 0.361
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ITGA3 0.2
Publications: 1 Organism: Homo Sapiens