| + |
MAOB | down-regulates quantity 
chemical modification
|
serotonin |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264015 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31024440 |
Following release, 5-HT receptor activation and reuptake by 5-HT transporter (5-HTT), serotonin is degraded by MAO (monoamine oxidase) and ALDH (aldehyde dehydrogenase) into 5-hydroxyindole-3-acetic acid (5-HIAA). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
moclobemide | down-regulates activity
chemical inhibition
|
MAOB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258315 |
|
|
in vitro |
|
| pmid |
sentence |
| 21680183 |
Twenty-two pyrazoline derivatives were synthesized and tested for their human MAO (hMAO) inhibitory activity. Twelve molecules with unsubstituted ring A and substituted ring C (5–16) were found to be potent inhibitors of hMAO-A isoform with SIMAO-A in the order 103 and 104. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SP3 | down-regulates quantity by repression 
transcriptional regulation
|
MAOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253870 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259630 |
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOB | up-regulates quantity 
chemical modification
|
(R)-noradrenaline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20493079 |
The selective monoamine oxidase inhibitors clorgyline and (−)-deprenyl were used to study the distribution of monoamine oxidase-A and -B (MAO-A, MAO-B) activities towards (−)-noradrenaline and (+),(−)-adrenaline in homogenates from seven different regions of human brain. Noradreanline and adrenaline were substrates for both forms of the enzyme in all regions studied. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
Phenelzine | down-regulates activity
chemical inhibition
|
MAOB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-257778 |
|
|
in vitro |
|
| pmid |
sentence |
| 18426226 |
Phenylethylhydrazine stoichiometrically reduces the covalent FAD moieties of MAO A and of MAO B. Molecular oxygen is required for the inhibition reactions, and the level of O2 consumption for phenylethylhydrazine is 6-7-fold higher with either MAO A or MAO B than for the corresponding reactions with benzylhydrazine or phenylhydrazine. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MAOB | down-regulates quantity
chemical modification
|
3-methoxytyramine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264000 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SP4 | up-regulates quantity by expression 
transcriptional regulation
|
MAOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253869 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259630 |
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EAPP | down-regulates quantity by repression
transcriptional regulation
|
MAOB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253867 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980443 |
we identified two novel transcriptional repressors of MAO B, E2F-associated phosphoprotein (EAPP) and R1 (RAM2/CDCA7L/JPO2), that down-regulate MAO B via MAO B core promoter, which contains Sp1 sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDCA7L | down-regulates quantity by repression
transcriptional regulation
|
MAOB |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253768 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20980443 |
we identified two novel transcriptional repressors of MAO B, E2F-associated phosphoprotein (EAPP) and R1 (RAM2/CDCA7L/JPO2), that down-regulate MAO B via MAO B core promoter, which contains Sp1 sites. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOB | up-regulates quantity
chemical modification
|
3,4-dihydroxyphenylacetaldehyde |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264004 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOB | up-regulates quantity
chemical modification
|
(R)-adrenaline |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20493079 |
The selective monoamine oxidase inhibitors clorgyline and (−)-deprenyl were used to study the distribution of monoamine oxidase-A and -B (MAO-A, MAO-B) activities towards (−)-noradrenaline and (+),(−)-adrenaline in homogenates from seven different regions of human brain. Noradreanline and adrenaline were substrates for both forms of the enzyme in all regions studied. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Brain |
| + |
(-)-selegiline | down-regulates activity
chemical inhibition
|
MAOB |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258136 |
|
|
in vitro |
|
| pmid |
sentence |
| 21377879 |
All the compounds were found as extremely potent and selective towards MAO-B, (Table 2) with at least 100 times more potent than the positive control selegiline. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SP1 | up-regulates quantity by expression
transcriptional regulation
|
MAOB |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253868 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11259630 |
Cotransfection experiments show that Sp1 and its closely related family member Sp4 can trans-activate MAO B promoter activity through the proximal cluster of Sp1 sites and its activation can be repressed by the over-expression of Sp3 and a related family member BTEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAOB | down-regulates quantity
chemical modification
|
dopamine |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| NBK536726 |
Dopamine is metabolized after reuptake into dopaminergic neurons or glial cells |dopamine is metabolized to 3-methoxytyramine by COMT, which is in turn converted to 3-methoxy-4-hydroxyacetaldehyde by MAO. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAOB
- 
- 