Summary

Name HTR1D
Full Name 5-hydroxytryptamine receptor 1D
Synonyms 5-HT-1D, 5-HT1D, Serotonin 1D alpha receptor, 5-HT-1D-alpha, Serotonin receptor 1D | HTR1DA, HTRL
Primary ID P28221
Links - -
Type protein
Relations 28
Inhibitors 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride; sertindole; zotepine; haloperidol; risperidone; paliperidone; pipamperone; 192927-92-7; 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAZ 0.251
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAO1 0.354
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNAI1 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding GNAI3 0.403
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Bos Taurus
Tissue: Brain
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding GNA14 0.251
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation HTR1D 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition HTR1D 0.8
Publications: 1 Organism: Rattus Norvegicus