Summary

Name HMOX2
Full Name Heme oxygenase 2
Synonyms HO-2 | HO2
Primary ID P30519
Links - -
Type protein
Relations 3
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation HMOX2 0.342
Publications: 1 Organism: Rattus Norvegicus
+ down-regulates activity img/direct_inhibition.png HBA1 0.256
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity img/direct_inhibition.png chemical modification heme 0.8
Publications: 1 Organism: Homo Sapiens